Large-scale production of tauroursodeoxycholic acid products through fermentation optimization of engineered Escherichia coli cell factory.

According to the principle that the smaller the P -value, the more significant the corresponding coefficient, it could be seen from Additional file 1 : Table S2 that two linear coefficient (factors A and D) and two quadratic coefficients (A^2 and D^2) were highly significant, indicating that glucose and yeast extract played important roles in the cell growth. 2 Y = 4.912 - 7.07 ∗ A + 0.81 ∗ B - 0.32 ∗ C + 1.04 ∗ D - 2.61 ∗ A ∗ B + 1.71 ∗ A ∗ C - 2.50 ∗ A ∗ D - 0.075 ∗ B ∗ C - 0.53 ∗ B ∗ D + 0.95 ∗ C ∗ D + 6.81 ∗ A ∗ A - 1.34 ∗ B ∗ B + 1.16 ∗ C ∗ C + 1.48 ∗ D ∗ D In Eq.

also in 132,142 other papers

The P -value of factor A in the model was below 0.0001, suggesting that factor A (glucose) was extremely significant correlated with the conversion efficiency but the other three factors were not significant ( P -value > 0.05) (Additional file 1 : Table S3).

also in 7,787 other papers