Sex Differences in Antidepressant Effect of Sertraline in Transgenic Mouse Models.

For the DA system, sertraline showed no effect on DA level and its metabolites in the PFC of all three genotype female mice (Figure 4A ), while sertraline showed a mild elevation of DA level and reduction of DA index in the HPC of female Thy1-Ar mice, and a marginally significant reduction of DOPAC and DA index levels in the HPC of female Ar +/− mice as compared to the vehicle-treated genotype-matched female mice (Figure 4B ).

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