Briefly, these authors reported highly significant negative correlations (controlling for age, sex, ethnicity and APOE allele status) between, on the one hand, TREM2 mRNA expression (following amplification by real-time quantitative polymerase chain reaction (qPCR)), and, on the other hand, MMSE score residuals, episodic memory score residuals and Montreal Cognitive Assessment (MoCA) score residuals; there was also a negative correlation with right hippocampal volume and with the grey matter (GM) volumes of the frontal, temporal and parietal cortices [ 135 ].
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The sentences
The differential elevation of mir-146a and miR-21 may be significant as they are associated with increased matrix metalloproteinase-9 (MMP-9) production and a corresponding increase in macrophage-associated tissue damage [ 125 ].