Correcting the R165K substitution in the first voltage-sensor of Ca<sub>V</sub>1.1 right-shifts the voltage-dependence of skeletal muscle calcium channel activation.

The mean voltage of half-maximal activation for the original Ca V 1.1e-K 165 was 6.9 ± 2.4 mV (N = 8) and for the corrected Ca V 1.1e-R 165 19.1 ± 1.3 mV (N = 8); the difference was statistically highly significant (P < 0.001) ( Table 1 ).

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