Point-of-care CRP matters: normal CRP levels reduce immediate antibiotic prescribing for acutely ill children in primary care: a cluster randomized controlled trial.

Elevated CRP levels did not significantly increase prescribing, except when no advice (C) could be given because the preliminary diagnosis and/or clinical indicators were lacking or unsure (borderline significance) (fully adjusted analysis: “no advice (C)”: aOR 1.82 (95% CI 1.01–3.27)) ( Figure 3 , Table 2 , Appendix 6 ).

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