Chronic helminth infection does not impair immune response to malaria transmission blocking vaccine Pfs230D1-EPA/Alhydrogel® in mice.

The Hpb-specific antibody response for the 2 Hpb-infected groups was characterized by a highly significant increase in the IgG1 but not IgG2a levels at day 63 post-infection, when compared with group 1 (naïve controls) and group 3 (vaccinated but not Hpb-infected mice) (1.42 ± 0.04 OD and 1.45 ± 0.04 OD vs. 0.02 ± 0.01 OD and 0.01 ± 0.01 OD, p < 0.01, respectively) ( Fig. 2 D and E).

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