Brain activation during disorder-related script-driven imagery in panic disorder: a pilot study.

Further inspection of brainstem ROI showed marginally significant hyperactivation in right brainstem to disorder-related vs. neutral scripts for PD patients compared to HC (peak voxel Talairach coordinates x = 3, y = −20, z = −18, max. t-value: t [33] = 3.00, p < 0.005 uncorrected; cluster size 16 mm 3 ) (Fig. 2 ).

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However, these findings have to be interpreted tentatively as brainstem hyperactivation only reached marginal significance (see Table 3 ).

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