Transcriptional regulation of Hepatic Stellate Cell activation in NASH.

Sci Rep · 2019 · PMC6382845 · PMID 30787418

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highly significantno p-value reported

By comparing with established models of HSC activation we show highly similar transcriptional dynamics in HSCs across models of in vivo activation and identify ETS1 and RUNX1 TF motifs as highly significant predictors of HSC gene induction in NASH and early fibrosis.

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failed to reach significanceno p-value reported

The expression of HSC activation markers Timp1 , Spp1 , Mmp3 , and Gas6 was significantly reduced upon MEK inhibition (FDR <0.05) whereas the reduction in Acta2 and Col1a1 expression failed to reach significance.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.