Effect of Chemokine (C-C Motif) Ligand 7 (CCL7) and Its Receptor (CCR2) Expression on Colorectal Cancer Behaviors.

Int J Mol Sci · 2019 · PMC6387027 · PMID 30764543

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might be significantno p-value reported

Similarly, a study on BALB/c nu/nu mice injected directly into cecum wall with hCCL7 overexpressing human colorectal HCT116 cells revealed metastasis formation both in the lungs (4/5) and in the liver (3/5); therefore, the type of cells, origin, and site of cancer cells inoculation (ectopic/subcutaneous or orthotropic/directly in colon wall) might be significant for the tropism of colon cancer cells to different organs [ 16 ].

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