Sulforaphane Protect Against Cadmium-Induced Oxidative Damage in mouse Leydigs Cells by Activating Nrf2/ARE Signaling Pathway.

Int J Mol Sci · 2019 · PMC6387384 · PMID 30717178

Europe PMC DOI

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extremely significantp < 0.05actually significant

Compared with the Cd group, the apoptosis of TM3 cells in the Cd + SFN2.5, Cd + SFN5 and Cd + SFN10 groups decreased, and the difference was extremely significant for the first two groups ( p < 0.05) and significant for the last group ( p < 0.01). 2.7.

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an increasing trendno p-value reported

The results showed that the cells independently treated with Cd or SFN demonstrated an increasing trend in the expression of Nrf2-signaling genes, with varying degrees of upregulation identified in either mRNAs or proteins of HO-1, NQO1 and γ-GCS.

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