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Development of Prediction Models Using Machine Learning Algorithms for Girls with Suspected Central Precocious Puberty: Retrospective Study.

JMIR Med Inform · 2019 · PMC6390190 · PMID 30747712

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a decreasing trendno p-value reported
In recent years, the age of puberty onset has shown a decreasing trend, and puberty is related to subsequent health outcomes such as breast cancer, diabetes, and behavioral disorders [ 1 ].

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.