It's a SMAD, SMAD World: Cell Type-Specific SMAD Signaling in the Heart.

JACC Basic Transl Sci · 2019 · PMC6390675 · PMID 30847419

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might be significantno p-value reported

The significant difference in cardiac myocyte physiology brought about by cell-specific SMAD4 deletion, not seen in the SMAD3-deleted myocyte-specific mice, suggests that signaling pathways associated with other BMP family members, in addition to TGF-β, might be significant for maintaining healthy cardiac myocyte activity in adult heart.

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