Barely Significant
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Cellular characterization of human epicardial adipose tissue: highly expressed PAPP-A regulates insulin-like growth factor I signaling in human cardiomyocytes.

Physiol Rep · 2019 · PMC6391584 · PMID 30809969

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The sentences

highly significantP < 0.0001actually significant
Despite age, sex, and procedural differences there was remarkable consistency in that in all 29 subjects, PAPP‐A levels in the conditioned medium of epicardial preadipocytes greatly exceeded those of subcutaneous preadipocytes, resulting in a highly significant 15‐fold difference by paired t ‐test ( P < 0.0001).

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