Association between Thalamocortical Functional Connectivity Abnormalities and Cognitive Deficits in Schizophrenia.

The two groups showed marginal significance in sex ratio (healthy subjects: 68.1% male subjects; psychosis: 83.1% male subjects; χ 2 1 = 3.87, p = 0.049), and the WASI FSIQ (four subtests) in the schizophrenia group was significantly lower than that in the healthy group (healthy subjects: 111.79 ± 11.92; psychosis: 100.89 ± 16.87; t 119 = −4.10, p < 0.001).

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These impairments are present at the first-psychotic episode 3 and clinically remitted states 4 , and schizophrenia patients who were never exposed to neuroleptics also show highly significant neuropsychological deficits 5 .

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