Phosphodiesterase beta is the master regulator of cAMP signalling during malaria parasite invasion.

Rupture events from RAP-treated schizonts showed a highly significant reduction in all three steps, suggesting that invasion by PDEβ-null merozoites is impaired upstream of tight junction formation ( Fig 4C and S3 – S7 Videos; the first two are wild type and the last three are knockout).

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