Vitamin D and its low calcemic analogs modulate the anticancer properties of cisplatin and dacarbazine in the human melanoma A375 cell line.

However, during prolonged incubation with cisplatin (48 h), the addition of 1,25(OH) 2 D3, but not 20(OH)D3, 21(OH)pD or calcipotriol, resulted in a decreasing trend in the relative IC 50 in comparison to cisplatin alone ( Fig. 2 ; Table II ), however the observed differences were not significant.

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