In agreement with the finding that KLF6 operated at least partially downstream of the HIF2A pathway, gene set enrichment analysis on the differentially expressed genes revealed a highly significant association between KLF6 -depletion and downregulation of the canonical hypoxia-response gene set (Supplementary Fig. 6a ).
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A KLF6-driven transcriptional network links lipid homeostasis and tumour growth in renal carcinoma.
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