Endogenous Gene Regulation as a Predicted Main Function of Type I-E CRISPR/Cas System in <i>E. coli</i>.

Molecules · 2019 · PMC6413058 · PMID 30795631

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highly significantno p-value reported

We find that CRISPR spacers have a statistically highly significant tendency to target (i) host compared to phage genomes, (ii) one of the two DNA strands, (iii) genomic dsDNA rather than mRNA, (iv) transcriptionally active regions, and (v) sequences ( cis -regulatory elements) with slower turn-over rate compared to CRISPR spacers ( trans -factors).

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