Proteomic analysis reveals dysregulated cell signaling in ejaculated spermatozoa from infertile men.

9 We have demonstrated an increasing trend in proteins involved in key biological processes during sperm maturation such as reproductive cellular process, gamete production, motility, oxidative phosphorylation, and energy metabolism.

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A decreasing trend was seen in the expression of proteins that were involved in key biological processes such as protein synthesis, protein transport, and response to oxidative stress. 9 Division of spermatozoa into phenotypes or subsets is of importance in the evaluation of its true fertility potential, particularly when using testicular spermatozoa for intracytoplasmic sperm injection (ICSI).

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