G-protein Gα₁₃ functions as a cytoskeletal and mitochondrial regulator to restrain osteoclast function.

Consistent with the phenotype of the enhanced ability of Gα 13 ΔM/ΔM osteoclasts for adhesion and actin ring organization, GO analysis revealed highly significant upregulation of genes involved in cytoskeleton, ruffle and adhesion (Fig. 6A ).

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