The renal transport protein OATP4C1 mediates uptake of the uremic toxin asymmetric dimethylarginine (ADMA) and efflux of cardioprotective L-homoarginine.

For ADMA and L-homoarginine these preloading experiments demonstrated a highly significant reduction in radioactivity in the lysate of HEK-OATP4C1 cells compared to HEK-VC cells, accompanied by a significant increase in radioactivity in the respective supernatant ( Fig 7A and 7B ).

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