Interaction of germline variants in a family with a history of early-onset clear cell renal cell carcinoma.

EGF is also important for thyroid metabolism (Mincione, et al., 2011 ), which may be significant, given the early thyroid cancer identified in the proband (Figure 1 ). 3.5 Additional maternally inherited variants The two affected siblings and the unaffected brother inherited a maternal TRAP1 variant, Thr535Ser, with a PM1 classification.

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