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Antimicrobial Susceptibility of <i>Streptococcus pneumoniae</i> from North America, Europe, Latin America, and the Asia-Pacific Region: Results From 20 Years of the SENTRY Antimicrobial Surveillance Program (1997-2016).

Open Forum Infect Dis · 2019 · PMC6419902 · PMID 30895211

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a decreasing trendno p-value reported
In NA, susceptibility rates to penicillin (≤0.06 mg/L), clindamycin, tetracycline, TMP-SMX, and erythromycin exhibited a decreasing trend until 2011–2012, but then increased until 2015–2016.

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