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Prevalence of Human Immunodeficiency Virus-1 Integrase Strand Transfer Inhibitor Resistance in British Columbia, Canada Between 2009 and 2016: A Longitudinal Analysis.

Open Forum Infect Dis · 2019 · PMC6419991 · PMID 30895202

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a decreasing trendno p-value reported
A decreasing trend in PI-RT resistance has recently been reported in other clinical HIV-positive populations [ 28 ] and may be attributed to the introduction of newer ARVs with greater genetic barriers to resistance.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.