Interleukin-22 protects intestinal stem cells against genotoxic stress.

Nature · 2019 · PMC6420091 · PMID 30700914

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highly significantno p-value reported

Using sporadic inactivation of IL-22Ra1 in colon epithelial stem cells, we found a highly significant reduction of apoptosis in IL-22Ra1-deficient crypts ( i.e ., Confetti + crypts) compared to IL-22Ra1-proficient crypts ( i.e. , Confetti - ) within the same mouse ( Fig. 3f,g ).

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