Transcriptomic analysis functionally maps the intrinsically disordered domain of EWS/FLI and reveals novel transcriptional dependencies for oncogenesis.

Using a 2-fold change in expression and an adjusted p -value < 0.05 as cutoffs, WT-EF rescues ~50% of both EWS/FLI activated and repressed genes, though this overlap is highly significant ( p < 0.0001, Figure 2D ).

also in 132,142 other papers