highly significantP < 0.0001
Among the two hiPSC lines, the highly significant ( P < 0.0001, paired t test with Bonferroni correction) reductions in methylation observed for the donor L1 during hiPSC derivation (25.0% on average) far exceeded that seen for the lineage progenitor (12.5%) and L1-Ta subfamily (2.9%) ( Fig. 5C and 6B ).