Also there may be significant differences between early-onset (familial) and late-onset (sporadic) AD such that treatments tested in existing models may be useful for early-onset AD but not for late-onset AD which is more common in human patients (Onos et al., 2016).
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Amelioration of Alzheimer's disease pathology and cognitive deficits by immunomodulatory agents in animal models of Alzheimer's disease.
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