Myalgic encephalomyelitis or chronic fatigue syndrome: how could the illness develop?

This may be significant from the perspective of exercise intolerance seen in ME/CFS as this kinase is responsible for sensing and enabling increased ATP production and maintaining metabolic homeostasis in striated muscle cells in response to increasing demands for energy during exercise (Morales-Alamo and Calbet 2016 ; Trewin et al. 2018 ).

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