highly significantp < .001
This finding was even more pronounced in LPMS where a highly significant increase in perivascular CD73 + CD271 + cells were detected in all lesions; CD73 was enriched 14‐fold ( p < .001) in active, 6‐fold ( p < .001) in chronic active lesions and 4‐fold ( p < .001) in chronic inactive compared to healthy controls, and CD271 increased 20‐fold ( p < .001) in active lesions, 11‐fold ( p < .001) in chronic active lesions and 2‐fold ( p < .001) in chronic inactive lesions compared to healthy tissue (Figs. 4 C, 4 D; Supporting Information Table 3).