Acetyltransferase p300 inhibitor reverses hypertension-induced cardiac fibrosis.

This observation is highly significant as firstly, it confirms that ATp300 inhibitors L002 and C646 are acting through epigenetic modifications; and secondly, differentiation of resident cardiac fibroblasts or endothelial cells to myofibroblasts and increased synthesis and secretion of collagen by myofibroblasts are major events in the progression of fibrogenesis [reviewed in 2 , 12 ].

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