Levels of phosphorylated p38 mitogen-activated protein kinase (p-p38 MAPK T180/Y182) were higher in dorsal NSPCs, and p-Akt S473, upstream of mTORC1, exhibited a nonsignificant trend towards higher levels in dorsal NSPCs, likely because of feedback from mTORC2 ( Fig S2C ).
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Location-dependent maintenance of intrinsic susceptibility to mTORC1-driven tumorigenesis.
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