The results of the experiment suggested a significant decrease in MFI of Rh123 in A2780 cells treated with Piperine, highly significant results were seen in cells treated with 16 and 20 μM of Piperine ( Figure 3 A), indicating that Piperine treatment induced destruction of ΔΨm in A2780 cells.
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Piperine functions as a tumor suppressor for human ovarian tumor growth via activation of JNK/p38 MAPK-mediated intrinsic apoptotic pathway.
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