Elevated DNA methylation across a 48-kb region spanning the HOXA gene cluster is associated with Alzheimer's disease neuropathology.

[ 7 ]; Supplementary Table 1 ) observing a similar pattern of effects with highly significant neuropathology-associated hypermethylation across probes in the HOXA genic region ( Fig. 2C ), and a significant correlation of effect size with the same 208 probes in the PFC in the discovery cohort ( Fig. 2D ; R = 0.80, P = 2.39 × 10 −48 ).

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