BRCA1 and Breast Cancer: a Review of the Underlying Mechanisms Resulting in the Tissue-Specific Tumorigenesis in Mutation Carriers.

Although the exact mechanism of this interaction still needs to be elucidated, evidence suggests a positive interaction with telomerase activity, increased stability of telomeres by deacetylation of certain histones (histone 4 lysine 16 deacetylation seems to be highly significant in this context) and enhanced activity of proteins involved in HR (e.g.

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