Ablation of the Chaperone Protein ERdj5 Results in a Sjögren's Syndrome-Like Phenotype in Mice, Consistent With an Upregulated Unfolded Protein Response in Human Patients.

Our mouse model exhibited higher levels of anti-SSA/Ro52 and antiSSA/Ro60 antibodies in females at the age of 7 months, and higher levels of anti-SSB/La antibodies in females at 12 months of age, providing clues for a possible trend that is not easily discernable in human patients who are usually diagnosed when the disease is already established: High anti-SSA/Ro52+60 antibodies might be a trait of early disease stages, while the anti-SSB/La antibodies may have delayed elevation with respect to disease development.

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