Metabolomics and Lipidomics Reveal the Effect of Hepatic <i>Vps33b</i> Deficiency on Bile Acids and Lipids Metabolism.

Front Pharmacol · 2019 · PMC6439481 · PMID 30967781

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Serum TG, which is one of the signatures of intrahepatic cholestasis of pregnancy and PFIC in the clinic ( Jankowska et al., 2016 ), showed an increasing trend in Vps33b flox/flox , alb-cre mice, which is consistent with the reduction of mRNA expression of fatty acid uptake genes Fatp2 and Fatp5 and TG synthesis genes.

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