highly significantp = 4.3 × 10 −7
Signature performance was driven by the highly significant associations of the arginine/WARS ( p = 4.3 × 10 −7 , τ = 0.43), cortisol/SOCS1 ( p = 7.4 × 10 −6 , τ = 0.28) and 5-oxoproline/LAP3 (5.8 × 10 −5 , τ = 0.37) pairs ( Figure S8 ).