Sequence and expression levels of circular RNAs in progenitor cell types during mouse corticogenesis.

Remarkably, when comparing the fraction of significant and nonsignificant ORFs within CiCo with the two control datasets, we found highly significant differences with both (chi-squared test, two-tailed P -value < 0.001) ( Fig 3B , right) suggesting that the coding potential of CiCo is not only an inherited feature resulting from their origin from coding genes but might potentially account for their function.

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