highly significantp < 0·0001
SRCV and VP demonstrated a highly significant upregulation for IFIT1 , MX1 , APOBEC3G and MX2 as compared to late but not early treated individuals ((SRCV: p < 0·0001, p < 0·0001, p < 0·0001, and p < 0·0001, respectively) and (VP: p < 0·0001, p < 0·0001, p = 0·006, p = 0·0002, respectively; Fig. 2 )).