NUP98 - a novel predictor of response to anthracycline-based chemotherapy in triple negative breast cancer.

A highly significant association between NUP98 expression and pathological complete response (pCR) ( p = 0.0057) was observed in patients treated with FEC – patients with low NUP98 expression were over twice as likely to achieve pCR as patients with high NUP98.

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Consistent with the gene expression analysis, any (intermediate or high) NUP98 protein expression was associated with an almost significant worse relapse free survival (HR 6.707 (95%CI 0.8815–51.04) p = 0.066) (Figure 3 a (i), Table 3 a).

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