Hypomorphic mutation of the mouse Huntington's disease gene orthologue.

PLoS Genet · 2019 · PMC6445486 · PMID 30897080

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highly significantno p-value reported

Gene Ontology and pathway enrichment analysis revealed highly significant enrichment of the Htt -inactivation sensitive RA-down gene set in developmental pathways related to organ system deficits observed in the hypomorphic mice: ‘skeletal system development’, ‘generation of neurons’, ‘blood vessel morphogenesis’, ‘blood vessel morphogenesis’, ‘skin development’ and ‘ear development’ ( S3 Fig ).

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