Early attempts to use weighted polygenic risk scores, were based on small numbers of highly significant SNPs identified from GWA studies, and achieved only limited predictive value for complex diseases ( Amin et al., 2009 ; Dudbridge, 2013 ).
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Early attempts to use weighted polygenic risk scores, were based on small numbers of highly significant SNPs identified from GWA studies, and achieved only limited predictive value for complex diseases ( Amin et al., 2009 ; Dudbridge, 2013 ).