Antinociceptive activity of petroleum ether fraction obtained from methanolic extract of Clinacanthus nutans leaves involves the activation of opioid receptors and NO-mediated/cGMP-independent pathway.

Concurrently, MOR given via oral administration at the dose of 5 mg/kg also caused a highly significant ( p < 0.001) prolongation of latency response starting at the interval of 60 min and lasted until the end of the experimentation (210 min).

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