In each analysis we found a highly significant enrichment of genes and/or miRNAs involved in TGF-β pathway signaling ( Figure 6C ). miR-432-5p Expression Is Higher in Biopsies from ER + Breast Cancer Patients with Intrinsic or Acquired CDK4/6 Inhibitor Resistance Compared to Those from Patients with Sensitive Disease Using miRNA-seq, we analyzed 44 tumor biopsies from patients who received CDK4/6 inhibitor treatment either with hormone therapy or as a monotherapy for metastatic ER + , FIER2 − breast cancer.
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MicroRNA-Mediated Suppression of the TGF-β Pathway Confers Transmissible and Reversible CDK4/6 Inhibitor Resistance.
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