The results revealed a highly significant correlation between the number of IL-17- or IFN-γ-secreting CD69 + CD4 + T RM cells and long-term protection against nasal colonization ( Figure 4 (e), supplementary Figure 2(a)).
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Immunization with whole cell but not acellular pertussis vaccines primes CD4 T<sub>RM</sub> cells that sustain protective immunity against nasal colonization with Bordetella pertussis.
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