Structure and mechanism of a Hypr GGDEF enzyme that activates cGAMP signaling to control extracellular metal respiration.

Comparison of K A|G to K 2A shows a 1.4-fold enhancement of ATP binding to the A-bound vs G-bound enzyme, but in this case the model fit is relatively insensitive to changes in K A|G value ( Figure 5B ), so this effect may or may not be significant.

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