By contrast, the combination treatment promoted a highly significant increase in the percentage of misaligned chromosomal DNA in a synergistic manner relative to the DMSO control or cells treated with CHIR99021 or paclitaxel on their own ( p = 0.01, 0.04 and 0.02 versus each of DMSO, CHIR99021 or paclitaxel alone).
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Tumor growth suppression using a combination of taxol-based therapy and GSK3 inhibition in non-small cell lung cancer.
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