While a highly significant association between EEG evidence of severe bilateral TCD and chronic sleep/wake dysregulation has been found in children ( Jan et al. 2011 ), the knockout of HCN3 in mice did not result in changed circadian functions ( Stieglitz et al. 2018 ).
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The Hyperpolarization-Activated HCN4 Channel is Important for Proper Maintenance of Oscillatory Activity in the Thalamocortical System.
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