This finding suggested an increasing trend for METTL3 and Zeb1 expression and a decreasing trend for Fbxo45 expression during the malignant transformation of CRC.
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m<sup>6</sup>A-induced lncRNA RP11 triggers the dissemination of colorectal cancer cells via upregulation of Zeb1.
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When RP11 expression was normalized to that of Siah1 (the relative levels of RP11 to that of Siah1) or Fbxo45, there was a trend towards significance for the reduced DFS of colon patients with higher RP11/Siah1 (Fig. 7 f) or RP11/Fbxo45 levels (Fig. 7 g) compared with patients with lower values.